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PTC596

Glpbio
Catalog No:GC38592-1mg CAS No.:1610964-64-1 MDLNo: Brand:Glpbio purity: 特性: Purpose:PTC596 是一種口服活性和選擇性的 B 細(xì)胞特異性莫洛尼氏鼠白血病病毒整合位點(diǎn) 1 (BMI-1) 抑制劑。PTC596 靶向腫瘤細(xì)胞和癌癥干細(xì)胞 (CSC) 均表達(dá)的 BMI1,并誘導(dǎo) BMI1 過度磷酸化,從而導(dǎo)致其降解。PTC596 可下調(diào) MCL-1 并誘導(dǎo)急性髓系白血病祖細(xì)胞中不依賴 p53 的線粒體凋亡。DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 5 mg/ml
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