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Home > Category > > Small Molecule Compound > PIN1 inhibitor API-1

PIN1 inhibitor API-1

Glpbio

Catalog No：GC38036-25mg CAS No.：680622-70-2 MDLNo： Brand:Glpbio purity： 特性： Purpose:PIN1 inhibitor API-1 是一種特殊的 Pin1 (peptidyl-prolyl cis-trans isomerase NIMA-interacting 1) 抑制劑 (API-1)，IC50 為 72.3 nM。PIN1 inhibitor API-1 直接特異性地與 Pin1 肽基脯氨酰異構(gòu)酶 (PPIase) 結(jié)構(gòu)域結(jié)合，并抑制 Pin1 順反異構(gòu)活性。PIN1 inhibitor API-1 保留 pXPO5 的活性構(gòu)象，恢復 pXPO5 將前 miRNA 從細胞核轉(zhuǎn)運到細胞質(zhì)的能力，從而上調(diào)抗癌 miRNA 的生物發(fā)生，抑制體外和體內(nèi)肝癌的發(fā)生。DMSO: 250 mg/mL (682.50 mM)

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Product Overview

Product Name	PIN1 inhibitor API-1
CAS	680622-70-2
Formula	C₁₅H₁₅F₃N₆O₂
MW	368.31
Storage condition	Store at -20°C

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PIN1 inhibitor API-1

PIN1 inhibitor API-1

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